• Squalane + Phyto-Retinol Serum
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  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum

Squalane + Phyto-Retinol Serum

439 reviews

Plant-derived retinol with niacinamide serum that fights signs of aging

Anti-aging Bakuchiol-based serum with niacinamide targets fine lines, wrinkles, and sun damage. Phyto-retinol serum acts like retinol, visibly fighting signs of aging without any sensitizing or irritating effects.
  • Full sizeSize: 30mL/1oz
  • EWG

  • Vegan

  • Cruelty Free

  • Nontoxic

  • Paraben free

  • Synthetic fragrance free

  • PEG free

Clinical Report

% Confirm

  • 100% agreed product felt gentle on the skin, but powerful on wrinkles*
  • 100% saw a visible improvement in wrinkles**
  • 100% agreed fine lines appear smoother***
If you thought you couldn’t get the benefits of retinol and niacinamide, think again.

A lightweight, powerfully effective squalane serum featuring Bakuchiol, a plant-derived alternative to retinol and niacinamide serum. Our Squalane Serum with Phyto-Retinol and niacinamide reduces the look of lines and wrinkles while visibly firming skin-without the irritation or sensitivity associated with retinol.
This No Compromise™ squalane serum formula was clinically evaluated and found to be non-irritating and effective for all skin types*.

  • Reduces the look of fine lines & wrinkles
  • Visibly improves firmness
  • Evens the look of skin tone
  • Retinol-free formula

For external use only. Use only as directed. We recommend a patch test prior to use if you are particularly sensitive. If irritation occurs, consult a dermatologist.

  • EWG

  • Vegan

  • Cruelty Free

  • Nontoxic

  • Paraben free

  • Synthetic fragrance free

  • PEG free


  • Massage 1-2 pumps of the squalane serum onto clean face and neck, morning and night.


    • Although this Squalane + Phyto-Retinol serum has a creamy consistency, it is a lightweight serum designed to be layered with other products. If you normally use moisturizer or oil, follow with Squalane + Probiotic Gel Moisturizer and/or Squalane + Vitamin C Rose Oil.
    • To boost hydration, mist clean skin with Squalane + Micronutrient Fine Mist, then apply Squalane + Phyto-Retinol Serum.
  • Step 1: Cleanser
  • Squalane + Elderberry Jelly Cleanser
  • Squalane + Antioxidant Cleansing Oil
  • Squalane + Tea Tree Cleansing Gel
  • Step 2: Mask
  • Squalane + Glycolic Renewal Facial
  • Step 3: Eye Treatment
  • Squalane + Peptide Eye Gel
  • Squalane + Marine Algae Eye Cream
  • Step 4: Treatment
  • Squalane + Phyto-Retinol Serum
  • Squalane + Lactic Acid Resurfacing Night Serum
  • Squalane + Vitamin C Dark Spot Serum
  • Step 5: Moisturizer
  • Squalane + Omega Repair Cream
  • Squalane + Probiotic Gel Moisturizer
  • Step 6: Oil
  • 100% Squalane Oil
  • Squalane + Vitamin C Rose Oil
  • Squalane + Tea Tree Balancing Oil
  • Step 7: Sunscreen
  • Squalane + Zinc Sheer Mineral Sunscreen
  • Step 8: Makeup
  • Apply foundation, BB/CC creams and any color cosmetics
  • Anytime: After Step 1, Over Makeup, or Throughout the Day
  • Squalane + Omega Repair Hand Cream
  • Squalane + Hyaluronic Toning Mist
  • Squalane + Rose Vegan Lip Balm
  • Hyaluronic Acid: water-retaining, molecules which visibly plump and support hydration on the skin’s delicate surface. Safe, non-irritating and deeply nourishing.
  • SQUALANE: Derived from sugarcane, it mimics body's natural hydrating oils to provide deep moisture and non-greasy, fast absorption.

All Ingredients:

Water/Aqua, Squalane, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Fruit Oil, Citrus Aurantium Amara (Bitter Orange) Peel Oil, Biosaccharide Gum-1, Yeast Extract, Soy Amino Acids, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Citric Acid, Linalool, Geraniol, Limonene


Customer Reviews
4.2 Based on 439 Reviews
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United States United States
Needs better packaging

Product is good but the packaging ruins it. The pump became useless before the halfway mark, and the rose gold coloring started to peel and flake around the same time. Tiny pieces would flake off onto my finger so I would have to be mindful of not getting it into the serum. I used this during my morning routine getting ready for work and during my nighttime routing getting ready for bed -- two times when I crave efficiency and a stress-free experience. The company comment about "nature of the packaging" and product expected to be "left over in the bottom" misses the point and deflects from the fact that the packaging is broken and needs to be fixed. Suggestion: a wide mouth cylinder screw top such as that used for the Squalane creams would be much simpler and better...and you already have it in-house! Is there a reason the serum needs to be pumped rather than scooped?

  • Skin Type Combination
  • Top Concern Uneven Tone & Dark Spots
  • Age 35-44

Hello, We appreciate your feedback and we would like to share that we acknowledge the packaging concern you and other customers have shared before. Biossance takes our customer's opinion very seriously and we guarantee you that we are working on a new bottle for our amazing Phyto-Retinol. Thanks for your love and support with us, Biossance Team

A Biossance Customer
Stacey .
United States United States
Greta product - silly bottle

Like almost every Biossance product I've purchased, I really like this. It feels so good when I out it on and my skin looks better over time. My only pet peeve: the bottle pump is very bad at getting the product out. I've never met a bottle like this -- flat bottom, skinny tube -- that adequately gets all the product. Eventually the tube stops suctioning it up and you have to turn the bottle upside own, let it settle, then remove the top and tap it out. I've gotten two extra weeks' worth of product by doing this and the fact that packagers continue to make this type of bottle -- and companies continue to use it -- baffles me. It's a pet peeve, but after decades of buying skin care products it adds to a lot of frustration and ultimately, makes me seek another product in a package that delivers it. So 5-stars for the product, minus 3 for the insane frustration of using all of it.

  • Skin Type Combination
  • Top Concern Redness & Sensitivity
  • Age 55

Thank you for reaching out and bringing this to our attention! We have had similar feedback regarding the tube inside our Phyto-Retinol Serum being too short. We have since produced longer tubes to help alleviate the problem, however, with the nature of the packaging, there will always be some product left over in the bottom that the tube will never be able to reach. We are always striving to improve our products and packaging so we will be sure to revisit your concerns to ensure that what we offer is top tier and effective.

United States United States
Horrible Bottle...Excellent Product!

I love this serum, not greasy at all. Super fresh and glowy feel without the shiny-ness. I am 39 w/combination skin and this did not make me break out at all. Packaging/Bottle is TERRIBLE, pump stopped working with lots of product still left at the bottom, had to jerry rig a solution to scrape the remainder out as it would be a complete waste to throw out that much when it’s $70/bottle. For god sakes, please fix this! Xoxo Delia

  • Skin Type Combination
  • Top Concern Age Prevention
  • Age 35-44
United States United States
Good product, bad packaging

Love the product but I won't be buying it until they change the packaging. Most of the time, product won't even come out and also way too much waste. Please change it asap.

  • Age 35-44

Hello, We appreciate your feedback and we would like to share that we acknowledge the packaging concern you and other customers have shared before. Biossance takes our customer's opinion very seriously and we guarantee you that we are working on a new bottle for our amazing Phyto-Retinol. Thanks for your love and support with us, Biossance Team

Nilgun D.
United States United States
Try the product first on a small area!!

First of all, I loveee Biossance products and I will continue to purchase! However, this product made my face swollen, left many red areas, bumps, and burning feel (for the first time in my life this happened). To me, all of this says I’m allergic to one/some of the ingredients! I tried the product before but same thing happened. Then I gave it a time (5 days) and tried again because I wanted this product to work! Unfortunately, this time my skin got more irritated (almost the entire face is red and left and right side of under eyes are swollen again)! My skin does not look healthy at all. Again this is the first time I have ever experienced this but I know that I have a very sensitive skin! I am writing this review so that if someone purchase this product and have a sensitive skin, they should try it on a small area first for couple of days!!! This is because nothing happened to me for the first day, it always irritated my skin second day! Waiting to see if it can actually calm again or need to see a dermatologist!!

  • Skin Type Sensitive
  • Top Concern Dry Skin
  • Age 25-34
Biossance Squalane + Phyto-Retinol Serum ReviewBiossance Squalane + Phyto-Retinol Serum Review

Thank you for sharing your experience with us! We’re so sorry that you’ve had a negative experience. All of our products have been thoroughly tested for safety and irritation and we always recommend a patch test prior to use if you are particularly sensitive. Unfortunately, you may have a personal sensitivity to an ingredient in the product. No matter how gentle something is, there may be a few people who can’t use it. If you haven’t already done so, please reach out to us at customerservice@biossance.com so we can better assist you or if you would like to return the product, please visit biossance.com/a/returns . Thanks, Biossance Team


Our commitment to people and planet applies to everything we create. We innovate every aspect of our company and supply chain to do better for our world and be the leading pioneers in sustainable beauty.


    Our squalane is derived from renewable sugarcane.

    Formulated using the latest sustainable methods. No deforestation and developed in far proximity from rainforests. Low water usage.

    Sugarcane and Forest Stewardship Council-certified boxes (FSC).

    Vegan, cruelty-free and nontoxic for people and the environment.

    All of our inner and outer cartons. (This excludes our airless bottle components and pumps.) We are working towards more sustainable solutions.
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