• Squalane + Phyto-Retinol Serum
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  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum
  • Squalane + Phyto-Retinol Serum

Squalane + Phyto-Retinol Serum

494 reviews

Plant-derived retinol serum with niacinamide that fights signs of aging

  • Full sizeSize: 30mL/1oz
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  • EWG

  • Vegan

  • Cruelty Free

  • Nontoxic

  • Paraben free

  • Synthetic fragrance free

  • PEG free

Clinical Report

% Confirm

  • 100% agreed product felt gentle on the skin, but powerful on wrinkles*
  • 100% saw a visible improvement in wrinkles**
  • 100% agreed fine lines appear smoother***
If you thought you couldn’t get the benefits of retinol and niacinamide, think again.

A lightweight, powerfully effective squalane serum featuring Bakuchiol, a plant-derived alternative to retinol and niacinamide serum. Our Squalane Serum with Phyto-Retinol and niacinamide reduces the look of lines and wrinkles while visibly firming skin-without the irritation or sensitivity associated with retinol.
This No Compromise™ squalane serum formula was clinically evaluated and found to be non-irritating and effective for all skin types*.

  • Reduces the look of fine lines & wrinkles
  • Visibly improves firmness
  • Evens the look of skin tone
  • Retinol-free formula

For external use only. Use only as directed. We recommend a patch test prior to use if you are particularly sensitive. If irritation occurs, consult a dermatologist.

  • EWG

  • Vegan

  • Cruelty Free

  • Nontoxic

  • Paraben free

  • Synthetic fragrance free

  • PEG free


  • Massage 1-2 pumps of the squalane serum onto clean face and neck, morning and night.


Layering Guide:

  • Step 1: Cleanser
  • Squalane + Elderberry Jelly Cleanser
  • Squalane + Antioxidant Cleansing Oil
  • Squalane + Tea Tree Cleansing Gel
  • Step 2: Toner
  • Squalane + BHA Pore Minimizing Toner
  • Step 3: Mask
  • Squalane + Glycolic Renewal Facial
  • Step 4: Eye Treatment
  • Squalane + Peptide Eye Gel
  • Squalane + Marine Algae Eye Cream
  • Step 5: Treatment
  • Squalane + Phyto-Retinol Serum
  • Squalane + Lactic Acid Resurfacing Night Serum
  • Squalane + Vitamin C Dark Spot Serum
  • Step 6: Moisturizer
  • Squalane + Omega Repair Cream
  • Squalane + Probiotic Gel Moisturizer
  • Step 7: Oil
  • 100% Squalane Oil
  • Squalane + Vitamin C Rose Oil
  • Squalane + Tea Tree Balancing Oil
  • Step 8: Sunscreen
  • Squalane + Zinc Sheer Mineral Sunscreen
  • Step 9: Makeup
  • Apply foundation, BB/CC creams and any color cosmetics
  • Anytime: After Step 1, Over Makeup, or Throughout the Day
  • Squalane + Omega Repair Hand Cream
  • Squalane + Hyaluronic Toning Mist
  • Squalane + Rose Vegan Lip Balm
  • Hyaluronic Acid: water-retaining, molecules which visibly plump and support hydration on the skin’s delicate surface. Safe, non-irritating and deeply nourishing.
  • SQUALANE: Derived from sugarcane, it mimics body's natural hydrating oils to provide weightless moisture to deliver active ingredients deep into the skin and prevent overdrying.

All Ingredients:

Water/Aqua, Squalane, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Fruit Oil, Citrus Aurantium Amara (Bitter Orange) Peel Oil, Biosaccharide Gum-1, Yeast Extract, Soy Amino Acids, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Citric Acid, Linalool, Geraniol, Limonene

  • 1What does "phyto" mean?

    Phyto comes from the Greek word “phyton” which means “plant”. When you see the word “phyto” it means that the product or ingredient comes from a plant source. We call our serum Phyto-Retinol because the main ingredient, bakuchiol, is a plant-derived retinol alternative.
  • 2How does bakuchiol work like retinol? How do you get the same benefits without the irritation?

    Bakuchiol works by mimicking the beneficial activity of retinol. In clinical studies, bakuchiol was found to target several of the same gene expression receptors as retinol, and had similar effects on boosting Collagen I, II and III. Bakuchiol also has strong antioxidant properties and is suitable for daytime use, unlike retinol.
  • 3Does Squalane + Phyto-Retinol Serum have the same restrictions as traditional retinol?

    No, the product is free of retinol or retinoids. The “retinol-like” effects come from bakuchiol, a plant-derived retinol alternative that has similar benefits, but because it works in a different way, doesn’t have the irritation or sun sensitivity associated with retinol.
  • 4Is this Squalane + Phyto-Retinol Serum safe to use during pregnancy or breastfeeding?

    Since Squalane + Phyto-Retinol Serum does not contain any retinol or retinoids, it does not have the same contraindications as retinol. However, as with any product applied to the skin we recommend checking with your doctor before using while pregnant or breastfeeding.


Customer Reviews
4.2 Based on 494 Reviews
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United States United States
Glad I added to routine

I do not love the smell (hence the 4 stars), but love the impact on my skin. I love that I can use a non-toxic and eco friendly product that works so well to smooth, plump, and hydrate my skin.

  • Skin Type Dry
  • Top Concern Age Prevention
  • Age 35-44
Diana k.
United States United States
Love this product

This product has given me great results, but my pump broke. Don't know how to get a new pump.

  • Skin Type Normal
  • Top Concern Fine Lines & Wrinkles
  • Age 55+
United States United States
Allergic reaction

I got a sample from Sephora. I had allergic reaction, swollen eyes, face red, itching, burning. I had to take a day off. So not recommending it at all.

  • Skin Type Combination
  • Top Concern Age Prevention
  • Age 45-54

Hello Asma- Thank you for telling us about your experience. We are so sorry you have had an adverse reaction and negative experience with our Phyto-Retinol Serum All of our products are formulated to the highest standards of safety and are thoroughly tested, and we always recommend a patch test prior to use if you are particularly sensitive. Unfortunately, you may have a personal sensitivity to an ingredient in the product. No matter how gentle something is, there may be a few people who can’t use it. If someone has not already done so, a valued member of our customer care team will reach out via customercare@biossance.com or you can reach out to us instantly on LiveChat or Video Chat by finding the gray chat bubble on the bottom right of Biossance.com. Thank you & have a wonderful day, The Biossance Team

United States United States
Great product

After buying the travel size to try out the retinol serum, I really liked it and my skin loves it.

  • Skin Type Combination
  • Top Concern
  • Age 25-34
United States United States
Skin changing!

I LOVE this product. My skin changed overnight (well maybe more over two nights, but that still was fast) and this was just what I was looking for after my face being sweating under a mask during those dry winter months. I feel so refreshed and my skin looks less stressed!

  • Skin Type Dry
  • Top Concern Age Prevention
  • Age 35-44


Our commitment to people and planet applies to everything we create. We innovate every aspect of our company and supply chain to do better for our world and be the leading pioneers in sustainable beauty.


    Our squalane is derived from renewable sugarcane.

    Formulated using the latest sustainable methods. No deforestation and developed in far proximity from rainforests. Low water usage.

    Sugarcane and Forest Stewardship Council-certified boxes (FSC).

    Vegan, cruelty-free and nontoxic for people and the environment.

    All of our inner and outer cartons. (This excludes our airless bottle components and pumps.) We are working towards more sustainable solutions.
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